Article
Retinal pigment epithelial cells induce foxp3(+) regulatory T cells via membrane-bound TGF-β.
Ocular immunology and inflammation - 1 Dec 2010
Vega Jose L, Saban Daniel, Carrier Yejun, Masli Sharmila, Weiner Howard L
Abstract excerpt
PURPOSE: It is speculated that retinal pigment epithelial (RPE) cells convert naïve T cells into regulatory T cells (Tregs) via soluble factors such as transforming growth factor beta (TGF-β). Yet presence or absence of similar membrane-bound mechanisms on RPE cells has yet to be addressed. Here the authors investigated the expression of surface TGF-β by RPE cells and its participation in the conversion of naive...
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