A mutation in the small (alpha) subunit of glycyl-tRNA synthetase affects amino acid activation and subunit association parameters.

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Article

A mutation in the small (alpha) subunit of glycyl-tRNA synthetase affects amino acid activation and subunit association parameters.

The Journal of biological chemistry - 15 Jan 1990

Toth M J, Schimmel P

Abstract excerpt

A strategy was designed to isolate mutants of glycyl-tRNA synthetase that are altered at the amino acid binding site, including a class with altered amino acid specificity. For this purpose, the plasmid pBR322 was mutated so that the codon (AGC) of the active site Ser-68 in the beta-lactamase gen...

Topics

Alleles
Amino Acids
Amino Acyl-tRNA Synthetases
Chromatography, Gel
Cloning, Molecular
Glycine-tRNA Ligase
Macromolecular Substances
Mutation
Plasmids
RNA, Transfer, Gly
Transfer RNA Aminoacylation
beta-Lactamases

Source

Open in PubMed

Identifiers

PMID: 2295596

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2295596-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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