Article
The 1-127 HA2 construct of influenza virus hemagglutinin induces cell-cell hemifusion.
Biochemistry - 27 Jul 2001
Leikina E, LeDuc D L, Macosko J C, Epand R, Epand R, Shin Y K, Chernomordik L V
Abstract excerpt
Conformational changes in the HA2 subunit of influenza hemagglutinin (HA) are coupled to membrane fusion. We investigated the fusogenic activity of the polypeptide FHA2 representing 127 amino-terminal residues of the ectodomain of HA2. While the conformation of FHA2 both at neutral and at low pH is nearly identical to the final low-pH conformation of HA2, FHA2 still induces lipid mixing between liposomes in a...
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