Article
Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin.
Annual review of biochemistry - 1 Jan 2000
Skehel J J, Wiley D C
Abstract excerpt
Hemagglutinin (HA) is the receptor-binding and membrane fusion glycoprotein of influenza virus and the target for infectivity-neutralizing antibodies. The structures of three conformations of the ectodomain of the 1968 Hong Kong influenza virus HA have been determined by X-ray crystallography: the single-chain precursor, HA0; the metastable neutral-pH conformation found on virus, and the fusion pH-induced...
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