Article
Development of a novel molecular sensor for imaging estrogen receptor-coactivator protein-protein interactions.
PloS one - 1 Jan 2012
Lake Madryn C, Nguyen Quang-Dé, Ali Simak, Aboagye Eric O
Abstract excerpt
Anti-estrogens, in particular tissue selective anti-estrogens, have been the bedrock of adjuvant therapy for patients with estrogen receptor alpha (ERα) positive breast cancer. Though current therapies have greatly enhanced patient prognosis, there continues to be an impetus for the development of improved anti-estrogens. ERα is a nuclear receptor transcription factor which activates gene expression through the...
Topics
Join the communities discussing this publication.