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Article

Novel biosensors for the detection of estrogen receptor ligands.

The Journal of steroid biochemistry and molecular biology - 1 Aug 2005

De Siddhartha, Macara Ian G, Lannigan Deborah A

Abstract excerpt

There exists a significant need for the detection of novel estrogen receptor (ER) ligands for pharmaceutical uses, especially for treating complications associated with menopause. We have developed fluorescence resonance energy transfer (FRET)-based biosensors that permit the direct in vitro detection of ER ligands. These biosensors contain an ER ligand-binding domain (LBD) flanked by the FRET donor fluorophore,...

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Androgens
Biosensing Techniques
Chlorocebus aethiops
COS Cells
Fluorescence Resonance Energy Transfer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Androgen

Receptors, Estrogen

Two-Hybrid System Techniques

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PMID: 15985367
DOI: 10.1016/j.jsbmb.2005.04.030

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