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Article

Purification and biochemical characterization of mutant ligand binding domain of human estrogen receptor α protein.

The Journal of steroid biochemistry and molecular biology - 1 Jul 2025

Palaniappan Murugesan, Bohren Kurt M

Abstract excerpt

The acquisition of mutations in the estrogen receptor alpha (ERα) gene (ESR1) is a key driver in the development of resistance to current endocrine therapy in breast cancer. Clinical studies have shown that ESR1 mutations are frequently observed in patients with metastatic ER-positive breast cancer and are associated with poor survival. Activating ESR1 somatic mutations, particularly Y537S and D538G, drive...

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Identifiers

PMID: 40245990
DOI: 10.1016/j.jsbmb.2025.106763

Genes

ESR1

Variants

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