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Article

IL-22 signaling contributes to West Nile encephalitis pathogenesis.

PloS one - 1 Jan 2012

Wang Penghua, Bai Fengwei, Zenewicz Lauren A, Dai Jianfeng, Gate David, Cheng Gong, Yang Long, Qian Feng, Yuan Xiaoling, Montgomery Ruth R, Flavell Richard A, Town Terrence, Fikrig Erol

Abstract excerpt

The Th17 cytokine, IL-22, regulates host immune responses to extracellular pathogens. Whether IL-22 plays a role in viral infection, however, is poorly understood. We report here that Il22(-/-) mice were more resistant to lethal West Nile virus (WNV) encephalitis, but had similar viral loads in the periphery compared to wild type (WT) mice. Viral loads, leukocyte infiltrates, proinflammatory cytokines and...

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Identifiers

PMID: 22952908
DOI: 10.1371/journal.pone.0044153
PMCID: PMC3429482

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