Article
Characterization of HPSE gene single nucleotide polymorphisms in Jewish populations of Israel.
Acta haematologica - 1 Jan 2007
Ostrovsky Olga, Korostishevsky Michael, Levite Iris, Leiba Merav, Galski Hanan, Gazit Ephraim, Vlodavsky Israel, Nagler Arnon
Abstract excerpt
Heparanase is a mammalian endoglucuronidase responsible for heparan sulfate (HS) degradation. HS is a major constituent of the extracellular matrix (ECM) and HS-degrading activity plays a decisive role in fundamental biological processes associated with remodeling of the ECM, such as cancer metastasis, angiogenesis and inflammation. There is great interest in the prospect of genome-wide association studies to...
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