GLCE rs3865014 (Val597Ile) polymorphism is associated with breast cancer susceptibility and triple-negative breast cancer in Siberian population.

doi:10.1016/j.gene.2017.07.054

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GLCE rs3865014 (Val597Ile) polymorphism is associated with breast cancer susceptibility and triple-negative breast cancer in Siberian population.

Gene - 10 Sept 2017

Belyavskaya Valentina A, Prudnikova Tatiana Y, Domanitskaya Natalya V, Litviakov Nikolay V, Maksimov Vladimir N, Cherdyntseva Nadezhda V, Grigorieva Elvira V

Abstract excerpt

d-Glucuronyl C5-epimerase (GLCE) is one of key enzymes in heparan sulfate biosynthesis and possesses tumour-suppressor function in breast carcinogenesis. Here, we investigated a potential involvement of GLCE polymorphism(s) in breast cancer development in Siberian women population. Comprehensive analysis of SNP databases revealed GLCE rs3865014 (Val597Ile) missense polymorphism as the main significantly present...

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PMID: 28734894
DOI: 10.1016/j.gene.2017.07.054

Genes

GLCE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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