Article
A deletion in the bovine FANCI gene compromises fertility by causing fetal death and brachyspina.
PloS one - 1 Jan 2012
Charlier Carole, Agerholm Jorgen Steen, Coppieters Wouter, Karlskov-Mortensen Peter, Li Wanbo, de Jong Gerben, Fasquelle Corinne, Karim Latifa, Cirera Susanna, Cambisano Nadine, Ahariz Naima, Mullaart Erik, Georges Michel, Fredholm Merete
Abstract excerpt
Fertility is one of the most important traits in dairy cattle, and has been steadily declining over the last decades. We herein use state-of-the-art genomic tools, including high-throughput SNP genotyping and next-generation sequencing, to identify a 3.3 Kb deletion in the FANCI gene causing the brachyspina syndrome (BS), a rare recessive genetic defect in Holstein dairy cattle. We determine that despite the very...
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