Article
Highly effective SNP-based association mapping and management of recessive defects in livestock.
Nature genetics - 1 Apr 2008
Charlier Carole, Coppieters Wouter, Rollin Frédéric, Desmecht Daniel, Agerholm Jorgen S, Cambisano Nadine, Carta Eloisa, Dardano Sabrina, Dive Marc, Fasquelle Corinne, Frennet Jean-Claude, Hanset Roger, Hubin Xavier, Jorgensen Claus, Karim Latifa, Kent Matthew, Harvey Kirsten, Pearce Brian R, Simon Patricia, Tama Nico, Nie Haisheng, Vandeputte Sébastien, Lien Sigbjorn, Longeri Maria, Fredholm Merete, Harvey Robert J, Georges Michel
Abstract excerpt
The widespread use of elite sires by means of artificial insemination in livestock breeding leads to the frequent emergence of recessive genetic defects, which cause significant economic and animal welfare concerns. Here we show that the availability of genome-wide, high-density SNP panels, combined with the typical structure of livestock populations, markedly accelerates the positional identification of genes...
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