Article
Estimating the numbers of malaria infections in blood samples using high-resolution genotyping data.
PloS one - 1 Jan 2012
Ross Amanda, Koepfli Cristian, Li Xiaohong, Schoepflin Sonja, Siba Peter, Mueller Ivo, Felger Ingrid, Smith Thomas
Abstract excerpt
People living in endemic areas often habour several malaria infections at once. High-resolution genotyping can distinguish between infections by detecting the presence of different alleles at a polymorphic locus. However the number of infections may not be accurately counted since parasites from multiple infections may carry the same allele. We use simulation to determine the circumstances under which the number...
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