Article
How much remains undetected? Probability of molecular detection of human Plasmodia in the field.
PloS one - 28 Apr 2011
Koepfli Cristian, Schoepflin Sonja, Bretscher Michael, Lin Enmoore, Kiniboro Benson, Zimmerman Peter A, Siba Peter, Smith Thomas A, Mueller Ivo, Felger Ingrid
Abstract excerpt
BACKGROUND: In malaria endemic areas, most people are simultaneously infected with different parasite clones. Detection of individual clones is hampered when their densities fluctuate around the detection limit and, in case of P. falciparum, by sequestration during part of their life cycle. This has important implications for measures of levels of infection or for the outcome of clinical trials. This study aimed...
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