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Article

Reversible inhibition of fusion activity of a paramyxovirus fusion protein by an engineered disulfide bond in the membrane-proximal external region.

Journal of virology - 1 Nov 2012

Zokarkar Aarohi, Connolly Sarah A, Jardetzky Theodore S, Lamb Robert A

Abstract excerpt

Cysteines were introduced into the membrane-proximal external region (MPER) of the paramyxovirus F protein. A disulfide bond formed, and the mutant protein was expressed at the cell surface but was fusion inactive. Reduction of the disulfide bond restored fusion activity. The data indicate that i...

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Identifiers

PMID: 22951841
DOI: 10.1128/JVI.02006-12
PMCID: PMC3486459

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22951841-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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