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Article

Contribution of cysteine residues in the extracellular domain of the F protein of human respiratory syncytial virus to its function.

Virology journal - 24 May 2006

Day Nicole D, Branigan Patrick J, Liu Changbao, Gutshall Lester L, Luo Jianquan, Melero José A, Sarisky Robert T, Del Vecchio Alfred M

Abstract excerpt

The mature F protein of all known isolates of human respiratory syncytial virus (HRSV) contains fifteen absolutely conserved cysteine (C) residues that are highly conserved among the F proteins of other pneumoviruses as well as the paramyxoviruses. To explore the contribution of the cysteines in the extracellular domain to the fusion activity of HRSV F protein, each cysteine was changed to serine. Mutation of...

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Identifiers

PMID: 16723026
DOI: 10.1186/1743-422X-3-34
PMCID: PMC1540417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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