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Article

Reversible inhibition of the fusion activity of measles virus F protein by an engineered intersubunit disulfide bridge.

Journal of virology - 1 Aug 2007

Lee Jin K, Prussia Andrew, Snyder James P, Plemper Richard K

Abstract excerpt

In search of target sites for the development of paramyxovirus inhibitors, we have engineered disulfide bridges to introduce covalent links into the prefusion F protein trimer of measles virus. F-Edm-452C/460C, predicted to bridge head and stalk domains of different F monomers, shows a high degree of proteolytic maturation and surface expression, predominantly as stable, dithiothreitol-sensitive trimers, but no...

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Identifiers

PMID: 17553889
DOI: 10.1128/JVI.00754-07
PMCID: PMC1951371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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