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Article

An inwardly rectifying K+ channel is required for patterning.

Development (Cambridge, England) - 1 Oct 2012

Dahal Giri Raj, Rawson Joel, Gassaway Brandon, Kwok Benjamin, Tong Ying, Ptácek Louis J, Bates Emily

Abstract excerpt

Mutations that disrupt function of the human inwardly rectifying potassium channel KIR2.1 are associated with the craniofacial and digital defects of Andersen-Tawil Syndrome, but the contribution of Kir channels to development is undefined. Deletion of mouse Kir2.1 also causes cleft palate and digital defects. These defects are strikingly similar to phenotypes that result from disrupted TGFβ/BMP signaling. We use...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22949619
DOI: 10.1242/dev.078592
PMCID: PMC3436115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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