The rs10757278 polymorphism of the 9p21.3 locus is associated with premature coronary artery disease in Polish patients.

doi:10.1089/gtmb.2012.0046

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Article

The rs10757278 polymorphism of the 9p21.3 locus is associated with premature coronary artery disease in Polish patients.

Genetic testing and molecular biomarkers - 1 Sept 2012

Niemiec Pawel, Gorczynska-Kosiorz Sylwia, Iwanicki Tomasz, Krauze Jolanta, Trautsolt Wanda, Grzeszczak Wladyslaw, Bochenek Andrzej, Zak Iwona

Abstract excerpt

Recently, genome-wide association studies have revealed a locus associated with coronary artery disease (CAD) and myocardial infarction, namely, 9p21.3. Its participation in the conditioning of the disease has been proven in many populations of European descent, but not yet in Slavs. Allelic variants of the rs10757278 polymorphism functionally affect the activity of the 9p21.3 locus; therefore, we conducted a...

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PMID: 22946666
DOI: 10.1089/gtmb.2012.0046
PMCID: PMC3438839

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