Article
Four SNPS on chromosome 9p21 confer risk to premature, familial CAD and MI in an American Caucasian population (GeneQuest).
Annals of human genetics - 1 Sept 2008
Abdullah K G, Li L, Shen G-Q, Hu Y, Yang Y, MacKinlay K G, Topol E J, Wang Q K
Abstract excerpt
Genome-wide association studies have separately identified four single nucleotide polymorphisms (SNPs) on chromosome 9p21 that confer susceptibility to coronary artery disease (CAD) and myocardial infarction (MI). This study presents the first analysis of these SNPs (rs10757274, rs2383206, rs2383207, and rs10757278) in a premature, familial CAD/MI population (GeneQuest). We performed a case-control analysis of...
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