Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling.

doi:10.1096/fj.05-3744fje

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Article

Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2005

Takeda Toshihiro, Asahi Michio, Yamaguchi Osamu, Hikoso Shungo, Nakayama Hiroyuki, Kusakari Yoichiro, Kawai Makoto, Hongo Kenichi, Higuchi Yoshiharu, Kashiwase Kazunori, Watanabe Tetsuya, Taniike Masayuki, Nakai Atsuko, Nishida Kazuhiko, Kurihara Satoshi, Donoviel Dorit B, Bernstein Alan, Tomita Taisuke, Iwatsubo Takeshi, Hori Masatsugu, Otsu Kinya

Abstract excerpt

Genetic studies of families with familial Alzheimer's disease have implicated presenilin 2 (PS2) in the pathogenesis of this disease. PS2 is ubiquitously expressed in various tissues including hearts. In this study, we examined cardiac phenotypes of PS2 knockout (PS2KO) mice to elucidate a role of PS2 in hearts. PS2KO mice developed normally with no evidence of cardiac hypertrophy and fibrosis. Invasive...

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PMID: 16204356
DOI: 10.1096/fj.05-3744fje

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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