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Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism

7 Jan 2020

Abstract excerpt

Bone remodeling consists of resorption by osteoclasts followed by formation by osteoblasts, and osteoclasts are a source of bone formation-stimulating factors. Here we utilize osteoclast ablation by denosumab (DMAb) and RNA-sequencing of bone biopsies from postmenopausal women to identify osteoclast-secreted factors suppressed by DMAb. Based on these analyses, LIF, CREG2, CST3, CCBE1, and DPP4 are likely...

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PMID: 31911667
DOI: 10.1038/s41467-019-14003-6

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