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Tregitope update: Mechanism of action parallels IVIg

28 Aug 2012

Abstract excerpt

In the course of screening immunoglobulin G (IgG) sequences for T cell epitopes, we identified novel Treg epitope peptides, now called Tregitopes, contained in the highly conserved framework regions of Fab and Fc. Tregitopes may provide one explanation for the expansion and stimulation of Treg cells following intravenous immunoglobulin (IVIg) therapy. Their distinguishing characteristics include in silico...

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PMID: 22944299
DOI: 10.1016/j.autrev.2012.08.017

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