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Modulation of CD8+ T cell responses to AAV vectors with IgG-derived MHC class II epitopes

16 Jul 2013

Abstract excerpt

Immune responses directed against viral capsid proteins constitute a main safety concern in the use of adeno-associated virus (AAV) as gene transfer vectors in humans. Pharmacological immunosuppression has been proposed as a solution to the problem; however, the approach suffers from several potential limitations. Using MHC class II epitopes initially identified within human IgG, named Tregitopes, we showed that...

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PMID: 23857231
DOI: 10.1038/mt.2013.166

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