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Article

Nuclear deformability depends on H3K9-methylated heterochromatin anchorage to the nuclear periphery in Caenorhabditis elegans.

Genetics - 9 Jul 2025

Gregory Ellen F, Luxton G W Gant, Starr Daniel A

Abstract excerpt

Nuclei adjust their deformability while migrating through constrictions to enable structural changes and maintain nuclear integrity. The effect of heterochromatin anchored at the nucleoplasmic face of the inner nuclear membrane on nuclear morphology and deformability during in vivo nuclear migration through constricted spaces remains unclear. Here, we show that abolishing peripheral heterochromatin anchorage by...

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Identifiers

PMID: 40335054
DOI: 10.1093/genetics/iyaf086
PMCID: PMC12239201

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MET

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