Aging magnifies the effects of dopamine transporter and D2 receptor genes on backward serial memory.

doi:10.1016/j.neurobiolaging.2012.08.001

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Article

Aging magnifies the effects of dopamine transporter and D2 receptor genes on backward serial memory.

Neurobiology of aging - 1 Jan 2013

Li Shu-Chen, Papenberg Goran, Nagel Irene E, Preuschhof Claudia, Schröder Julia, Nietfeld Wilfried, Bertram Lars, Heekeren Hauke R, Lindenberger Ulman, Bäckman Lars

Abstract excerpt

Aging compromises dopamine transporter (DAT) and receptor mechanisms in the frontostriatal circuitry. In a sample of 1288 younger and older adults, we investigated (i) whether individual differences in genotypes of the DAT gene (i.e., SLC6A3, the DAT variable number of tandem repeat 9/9, 9/10, and 10/10) and in the D2 receptor (DRD2) gene (i.e., the C957T [rs6277] CC and any T) interactively contribute to...

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Identifiers

PMID: 22939506
DOI: 10.1016/j.neurobiolaging.2012.08.001

Genes

DRD2

Variants

rs6277

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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