Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

A novel in vitro model system for smooth muscle differentiation from human embryonic stem cell-derived mesenchymal cells.

American journal of physiology. Cell physiology - 15 Feb 2013

Guo Xia, Stice Steven L, Boyd Nolan L, Chen Shi-You

Abstract excerpt

The objective of this study was to develop a novel in vitro model for smooth muscle cell (SMC) differentiation from human embryonic stem cell-derived mesenchymal cells (hES-MCs). We found that hES-MCs were differentiated to SMCs by transforming growth factor-β (TGF-β) in a dose- and time-dependent manner as demonstrated by the expression of SMC-specific genes smooth muscle α-actin, calponin, and smooth muscle...

Topics

Antigens, Differentiation
Calcium Signaling
Cell Culture Techniques
Cell Differentiation
Cell Shape
Cells, Cultured
Coculture Techniques
Embryonic Stem Cells
Endothelial Cells
Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Mesenchymal Stem Cells

Muscle Contraction

Muscle Development

Muscle, Smooth

Myocytes, Smooth Muscle

Nuclear Proteins

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 23220114
DOI: 10.1152/ajpcell.00298.2012
PMCID: PMC3566539

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel in vitro model system for smooth muscle differentiation from human embryonic stem cell-derived mesenchymal cells.PMID 23220114Read ↗

A Comparison of Murine Smooth Muscle Cells Generated from Embryonic versus Induced Pluripotent Stem CellsSemantic proximity Read ↗

Derivation of Smooth Muscle Cells with Neural Crest Origin from Human Induced Pluripotent Stem CellsSemantic proximity Read ↗

Smooth muscle cell differentiation in vitro: models and underlying molecular mechanisms.Semantic proximity Read ↗

Smooth muscle stem cellsSemantic proximity Read ↗

Functional vascular smooth muscle cells derived from human induced pluripotent stem cells via mesenchymal stem cell intermediates.Semantic proximity Read ↗

Myocardin overexpression is sufficient for promoting the development of a mature smooth muscle cell-like phenotype from human embryonic stem cells.Semantic proximity Read ↗

The mechanism of stem cell differentiation into smooth muscle cellsSemantic proximity Read ↗

Generation and Characterization of Human Mesenchymal Stem Cell-Derived Smooth Muscle CellsSemantic proximity Read ↗

Human induced pluripotent stem cell-derived vascular smooth muscle cells: differentiation and therapeutic potentialSemantic proximity Read ↗

Transforming Growth Factor-β and Notch Signaling Mediate Stem Cell Differentiation into Smooth Muscle CellsSemantic proximity Read ↗

Regulation of differentiation of vascular smooth muscle cellsSemantic proximity Read ↗

Derivation and maturation of synthetic and contractile vascular smooth muscle cells from human pluripotent stem cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.