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Article

The TT genotype of the STAT4 rs7574865 polymorphism is associated with high disease activity and disability in patients with early arthritis.

PloS one - 1 Jan 2012

Lamana Amalia, Balsa Alejandro, Rueda Blanca, Ortiz Ana M, Nuño Laura, Miranda-Carus Maria Eugenia, Gonzalez-Escribano Maria F, Lopez-Nevot Miguel A, Pascual-Salcedo Dora, Martin Javier, González-Álvaro Isidoro

Abstract excerpt

BACKGROUND: The number of copies of the HLA-DRB1 shared epitope, and the minor alleles of the STAT4 rs7574865 and the PTPN22 rs2476601 polymorphisms have all been linked with an increased risk of developing rheumatoid arthritis. In the present study, we investigated the effects of these genetic variants on disease activity and disability in patients with early arthritis. METHODOLOGY AND RESULTS: We studied 640...

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Source

Open in PubMed Open full text

Identifiers

PMID: 22937072
DOI: 10.1371/journal.pone.0043661
PMCID: PMC3427144

Genes

STAT4
PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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The TT genotype of the STAT4 rs7574865 polymorphism is associated with high disease activity and disability in patients with early arthritis.PMID 22937072Read ↗

The Minor Allele of rs7574865 in the STAT4 Gene Is Associated with Increased mRNA and Protein Expression.Semantic proximity Read ↗

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STAT4 rs7574865 G/T polymorphism is associated with rheumatoid arthritis and disease activity, but not with anti-CCP antibody levels in a Mexican population.Semantic proximity Read ↗

Association of STAT4 with rheumatoid arthritis: a replication study in three European populations.Semantic proximity Read ↗

Do Genetic Susceptibility Variants Associate with Disease Severity in Early Active Rheumatoid Arthritis?Semantic proximity Read ↗

Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases.Semantic proximity Read ↗

Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.Semantic proximity Read ↗

Combined influence of genetic and environmental factors in age of rheumatoid arthritis onset.Semantic proximity Read ↗

Replication study of STAT4 rs7574865 G/T polymorphism and risk of rheumatoid arthritis in a Chinese population.Semantic proximity Read ↗

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Both baseline clinical factors and genetic polymorphisms influence the development of severe functional status in ankylosing spondylitis.Semantic proximity Read ↗

Association between the rs7574865 polymorphism of STAT4 and rheumatoid arthritis: a meta-analysis.Semantic proximity Read ↗

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