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Article

Combined influence of genetic and environmental factors in age of rheumatoid arthritis onset.

Rheumatology international - 1 Oct 2012

Rodríguez-Rodríguez Luis, Lamas José Ramón, Varadé Jezabel, Tornero-Esteban Pilar, Abasolo Lydia, de la Concha Emilio Gomez, Jover Juan Angel, Urcelay Elena, Fernández-Gutiérrez Benjamín

Abstract excerpt

To study the combined effect of both genetic and environmental factors in the age of rheumatoid arthritis onset. Patients (n = 507). Shared epitope characterization was performed using Lifecodes HLA-SSO. Genotyping of protein tyrosine phosphatase non-receptor 22 (PTPN22) rs2476601 and signal transducers and activators of transcription 4 (STAT4) rs7574865 polymorphism was performed using fast real-time PCR System....

Read the complete abstract on PubMed

Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autoantibodies
Share to Educational Status
Share to Epitopes
Share to HLA-DRB1 Chains
Share to Linear Models
Share to Peptides, Cyclic
Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22
Share to STAT4 Transcription Factor

Source

Identifiers

PMID: 21922340
DOI: 10.1007/s00296-011-2090-9

Genes

PTPN22
STAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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