Article
Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.
PloS one - 29 Apr 2010
Glas Jürgen, Seiderer Julia, Nagy Melinda, Fries Christoph, Beigel Florian, Weidinger Maria, Pfennig Simone, Klein Wolfram, Epplen Jörg T, Lohse Peter, Folwaczny Matthias, Göke Burkhard, Ochsenkühn Thomas, Diegelmann Julia, Müller-Myhsok Bertram, Roeske Darina, Brand Stephan
Abstract excerpt
BACKGROUND: Recent studies demonstrated an association of STAT4 variants with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), indicating that multiple autoimmune diseases share common susceptibility genes. We therefore investigated the influence of STAT4 variants on the susceptibility and phenotype of inflammatory bowel diseases (IBD) in a large patient and control cohort. METHODOLOGY/PRINCIPAL...
Topics
- Age of Onset
- Autoimmune Diseases
- Case-Control Studies
- Crohn Disease
- Genetic Predisposition to Disease
- Humans
- Inflammatory Bowel Diseases
- Polymorphism, Single Nucleotide
- Receptors, Interleukin