Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.

PloS one - 29 Apr 2010

Glas Jürgen, Seiderer Julia, Nagy Melinda, Fries Christoph, Beigel Florian, Weidinger Maria, Pfennig Simone, Klein Wolfram, Epplen Jörg T, Lohse Peter, Folwaczny Matthias, Göke Burkhard, Ochsenkühn Thomas, Diegelmann Julia, Müller-Myhsok Bertram, Roeske Darina, Brand Stephan

Abstract excerpt

BACKGROUND: Recent studies demonstrated an association of STAT4 variants with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), indicating that multiple autoimmune diseases share common susceptibility genes. We therefore investigated the influence of STAT4 variants on the susceptibility and phenotype of inflammatory bowel diseases (IBD) in a large patient and control cohort. METHODOLOGY/PRINCIPAL...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Autoimmune Diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Crohn Disease

Share to Inflammatory Bowel Diseases

Share to Polymorphism, Single Nucleotide

Share to Receptors, Interleukin

Share to STAT4 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 20454450
DOI: 10.1371/journal.pone.0010373
PMCID: PMC2861592

Genes

STAT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.PMID 20454450Read ↗

Association of STAT4 rs7574865 polymorphism with susceptibility to inflammatory bowel disease: A systematic review and meta-analysis.Semantic proximity Read ↗

STAT4 gene influences genetic predisposition to ulcerative colitis but not Crohn's disease in the Spanish population: a replication study.Semantic proximity Read ↗

Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease.Semantic proximity Read ↗

A single nucleotide polymorphism in the STAT5 gene favors colonic as opposed to small-bowel inflammation in Crohn's disease.Semantic proximity Read ↗

Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases.Semantic proximity Read ↗

Associations between STAT3 rs744166 polymorphisms and susceptibility to ulcerative colitis and Crohn's disease: a meta-analysis.Semantic proximity Read ↗

The G2964A polymorphism of the STAT6 gene in inflammatory bowel disease.Semantic proximity Read ↗

Association of STAT4 rs7574865 polymorphism with autoimmune diseases: a meta-analysis.Semantic proximity Read ↗

Abnormal genetic and epigenetic changes in signal transducer and activator of transcription 4 in the pathogenesis of inflammatory bowel diseases.Semantic proximity Read ↗

Association between STAT3 gene polymorphisms and Crohn's disease susceptibility: a case-control study in a Chinese Han population.Semantic proximity Read ↗

Two independent genetic factors responsible for the associations of the IBD5 locus with Crohn's disease in the Czech population.Semantic proximity Read ↗

An analysis of genetic factors related to risk of inflammatory bowel disease and colon cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.