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Article

H1N1 2009 pandemic influenza virus: resistance of the I223R neuraminidase mutant explained by kinetic and structural analysis.

PLoS pathogens - 1 Sept 2012

van der Vries Erhard, Collins Patrick J, Vachieri Sebastien G, Xiong Xiaoli, Liu Junfeng, Walker Philip A, Haire Lesley F, Hay Alan J, Schutten Martin, Osterhaus Albert D M E, Martin Steve R, Boucher Charles A B, Skehel John J, Gamblin Steve J

Abstract excerpt

Two classes of antiviral drugs, neuraminidase inhibitors and adamantanes, are approved for prophylaxis and therapy against influenza virus infections. A major concern is that antiviral resistant viruses emerge and spread in the human population. The 2009 pandemic H1N1 virus is already resistant to adamantanes. Recently, a novel neuraminidase inhibitor resistance mutation I223R was identified in the neuraminidase...

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Identifiers

PMID: 23028314
DOI: 10.1371/journal.ppat.1002914
PMCID: PMC3447749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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