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Article

Impact of mutations at residue I223 of the neuraminidase protein on the resistance profile, replication level, and virulence of the 2009 pandemic influenza virus.

Antimicrobial agents and chemotherapy - 1 Mar 2012

Pizzorno Andrés, Abed Yacine, Bouhy Xavier, Beaulieu Edith, Mallett Corey, Russell Rupert, Boivin Guy

Abstract excerpt

Amino acid substitutions at residue I223 of the neuraminidase (NA) protein have been identified in 2009 pandemic influenza (pH1N1) variants with altered susceptibilities to NA inhibitors (NAIs). We used reverse genetics and site-directed mutagenesis to generate the recombinant A/Québec/144147/09 pH1N1 wild-type virus (WT) and five (I223R, I223V, H275Y, I223V-H275Y, and I223R-H275Y) NA mutants. A fluorimetry-based...

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PMID: 22203589
DOI: 10.1128/AAC.05994-11
PMCID: PMC3294894

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