Article
Feed-forward loop circuits as a side effect of genome evolution.
Molecular biology and evolution - 1 Oct 2006
Cordero Otto X, Hogeweg Paulien
Abstract excerpt
In this article, we establish a connection between the mechanics of genome evolution and the topology of gene regulation networks, focusing in particular on the evolution of the feed-forward loop (FFL) circuits. For this, we design a model of stochastic duplications, deletions, and mutations of binding sites and genes and compare our results with yeast network data. We show that the mechanics of genome evolution...
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