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Article

Dynamics of genetic variation in transcription factors and its implications for the evolution of regulatory networks in Bacteria.

Nucleic acids research - 7 May 2020

Ali Farhan, Seshasayee Aswin Sai Narain

Abstract excerpt

The evolution of regulatory networks in Bacteria has largely been explained at macroevolutionary scales through lateral gene transfer and gene duplication. Transcription factors (TF) have been found to be less conserved across species than their target genes (TG). This would be expected if TFs accumulate mutations faster than TGs. This hypothesis is supported by several lab evolution studies which found TFs,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32182360
DOI: 10.1093/nar/gkaa162
PMCID: PMC7192604

Genes

TF
TG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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