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Article

Prenatal low dosage dioxin (TCDD) exposure impairs cochlear function resulting in auditory neuropathy.

Hearing research - 1 Jan 2016

Safe Theresa M, Luebke Anne E

Abstract excerpt

2,3,7,8-tetrachorodibenzo-p-dioxin (TCDD), a ubiquitous and persistent environmental contaminant, is a potent teratogen. Whereas developmental TCDD toxicity is mediated by the aryl hydrocarbon receptor (AhR), the normal function of the AhR is poorly understood. We tested whether dioxin exposure during a critical period of hair cell development disrupts cochlear function in three mouse strains, (C57BL6, BalbC, and...

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Share to Cochlea
Share to Evoked Potentials, Auditory, Brain Stem
Share to Hydrocarbons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Maternal Exposure

Share to Otoacoustic Emissions, Spontaneous

Share to Polychlorinated Dibenzodioxins

Share to Pregnancy, Animal

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Source

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Identifiers

PMID: 26464051
DOI: 10.1016/j.heares.2015.09.015
PMCID: PMC4706485

Genes

ABR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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