Article
Adaptive linear rank tests for eQTL studies.
Statistics in medicine - 10 Feb 2013
Szymczak Silke, Scheinhardt Markus O, Zeller Tanja, Wild Philipp S, Blankenberg Stefan, Ziegler Andreas
Abstract excerpt
Expression quantitative trait loci (eQTL) studies are performed to identify single-nucleotide polymorphisms that modify average expression values of genes, proteins, or metabolites, depending on the genotype. As expression values are often not normally distributed, statistical methods for eQTL studies should be valid and powerful in these situations. Adaptive tests are promising alternatives to standard...
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