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Article

Statistical considerations for the analysis of massively parallel reporter assays data.

Genetic epidemiology - 1 Oct 2020

Qiao Dandi, Zigler Corwin M, Cho Michael H, Silverman Edwin K, Zhou Xiaobo, Castaldi Peter J, Laird Nan H

Abstract excerpt

Noncoding DNA contains gene regulatory elements that alter gene expression, and the function of these elements can be modified by genetic variation. Massively parallel reporter assays (MPRA) enable high-throughput identification and characterization of functional genetic variants, but the statistical methods to identify allelic effects in MPRA data have not been fully developed. In this study, we demonstrate how...

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Identifiers

PMID: 32681690
DOI: 10.1002/gepi.22337
PMCID: PMC7722129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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