Article
Glycans flanking the hypervariable connecting peptide between the A and B strands of the V1/V2 domain of HIV-1 gp120 confer resistance to antibodies that neutralize CRF01_AE viruses.
PloS one - 1 Jan 2015
O'Rourke Sara M, Sutthent Ruengpung, Phung Pham, Mesa Kathryn A, Frigon Normand L, To Briana, Horthongkham Navin, Limoli Kay, Wrin Terri, Berman Phillip W
Abstract excerpt
Understanding the molecular determinants of sensitivity and resistance to neutralizing antibodies is critical for the development of vaccines designed to prevent HIV infection. In this study, we used a genetic approach to characterize naturally occurring polymorphisms in the HIV envelope protein that conferred neutralization sensitivity or resistance. Libraries of closely related envelope genes, derived from...
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