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Article

Human CRM1 augments production of infectious human and feline immunodeficiency viruses from murine cells.

Journal of virology - 1 Nov 2012

Elinav Hila, Wu Yuanfei, Coskun Ayse, Hryckiewicz Katarzyna, Kemler Iris, Hu Yani, Rogers Hilary, Hao Bing, Ben Mamoun Choukri, Poeschla Eric, Sutton Richard

Abstract excerpt

Productive replication of human immunodeficiency virus type 1 (HIV-1) occurs efficiently only in humans. The posttranscriptional stages of the HIV-1 life cycle proceed poorly in mouse cells, with a resulting defect in viral assembly and release. Previous work has shown that the presence of human chromosome 2 increases HIV-1 production in mouse cells. Recent studies have shown that human chromosome region...

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Identifiers

PMID: 22933280
DOI: 10.1128/JVI.01970-12
PMCID: PMC3486471

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