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Low-density lipoprotein receptor–related protein 1 (LRP1) as an auxiliary host factor for RNA viruses

18 Apr 2023

Abstract excerpt

Viruses with an RNA genome are often the cause of zoonotic infections. In order to identify novel pro-viral host cell factors, we screened a haploid insertion–mutagenized mouse embryonic cell library for clones that are resistant to Rift Valley fever virus (RVFV). This screen returned the low-density lipoprotein receptor–related protein 1 (LRP1) as a top hit, a plasma membrane protein involved in a wide variety...

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PMID: 37072184
DOI: 10.26508/lsa.202302005

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