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Bluetongue virus non-structural protein 1 is a positive regulator of viral protein synthesis

29 Aug 2012

Abstract excerpt

BACKGROUND: Bluetongue virus (BTV) is a double-stranded RNA (dsRNA) virus of the Reoviridae family, which encodes its genes in ten linear dsRNA segments. BTV mRNAs are synthesised by the viral RNA-dependent RNA polymerase (RdRp) as exact plus sense copies of the genome segments. Infection of mammalian cells with BTV rapidly replaces cellular protein synthesis with viral protein synthesis, but the regulation of...

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PMID: 22931514
DOI: 10.1186/1743-422x-9-178

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