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Detection of a Fourth Orbivirus Non-Structural Protein

12 Oct 2011

Abstract excerpt

The genus Orbivirus includes both insect and tick-borne viruses. The orbivirus genome, composed of 10 segments of dsRNA, encodes 7 structural proteins (VP1-VP7) and 3 non-structural proteins (NS1-NS3). An open reading frame (ORF) that spans almost the entire length of genome segment-9 (Seg-9) encodes VP6 (the viral helicase). However, bioinformatic analysis recently identified an overlapping ORF (ORFX) in Seg-9....

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PMID: 22022432
DOI: 10.1371/journal.pone.0025697

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