Article

Both the low-density lipoprotein receptor and apolipoprotein E define blood-borne high-density lipoprotein entry into the brain

2025-05-28

Abstract excerpt

Data from epidemiological and genetic studies as well as animal experiments indicate that high-density lipoproteins (HDL) play a role in the pathogenesis of central nervous system (CNS) diseases. Apolipoprotein A-I, the major protein of HDL, has been immunolocalized in the brain although it is produced exclusively by the liver and intestine. We therefore investigated how HDL cross the blood-brain barrier (BBB), us...

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Literature Corpus work: ae625697-a17e-534d-95b7-281dc6d36af9
DOI: 10.1101/2025.05.23.655828

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