Article
Poly-gene fusion transcripts and chromothripsis in prostate cancer.
Genes, chromosomes & cancer - 1 Dec 2012
Wu Chunxiao, Wyatt Alexander W, McPherson Andrew, Lin Dong, McConeghy Brian J, Mo Fan, Shukin Robert, Lapuk Anna V, Jones Steven J M, Zhao Yongjun, Marra Marco A, Gleave Martin E, Volik Stanislav V, Wang Yuzhuo, Sahinalp S Cenk, Collins Colin C
Abstract excerpt
Complex genome rearrangements are frequently observed in cancer but their impact on tumor molecular biology is largely unknown. Recent studies have identified a new phenomenon involving the simultaneous generation of tens to hundreds of genomic rearrangements, called chromothripsis. To understand the molecular consequences of these events, we sequenced the genomes and transcriptomes of two prostate tumors...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.