Article
From sequence to molecular pathology, and a mechanism driving the neuroendocrine phenotype in prostate cancer.
The Journal of pathology - 1 Jul 2012
Lapuk Anna V, Wu Chunxiao, Wyatt Alexander W, McPherson Andrew, McConeghy Brian J, Brahmbhatt Sonal, Mo Fan, Zoubeidi Amina, Anderson Shawn, Bell Robert H, Haegert Anne, Shukin Robert, Wang Yuzhuo, Fazli Ladan, Hurtado-Coll Antonio, Jones Edward C, Hach Faraz, Hormozdiari Fereydoun, Hajirasouliha Iman, Boutros Paul C, Bristow Robert G, Zhao Yongjun, Marra Marco A, Fanjul Andrea, Maher Christopher A, Chinnaiyan Arul M, Rubin Mark A, Beltran Himisha, Sahinalp S Cenk, Gleave Martin E, Volik Stanislav V, Collins Colin C
Abstract excerpt
The current paradigm of cancer care relies on predictive nomograms which integrate detailed histopathology with clinical data. However, when predictions fail, the consequences for patients are often catastrophic, especially in prostate cancer where nomograms influence the decision to therapeutically intervene. We hypothesized that the high dimensional data afforded by massively parallel sequencing (MPS) is not...
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