Article
Non-small-cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation.
Cancer research - 1 Oct 2006
Das Amit K, Sato Mitsuo, Story Michael D, Peyton Michael, Graves Robert, Redpath Stella, Girard Luc, Gazdar Adi F, Shay Jerry W, Minna John D, Nirodi Chaitanya S
Abstract excerpt
Non-small cell lung cancers (NSCLCs) bearing mutations in the tyrosine kinase domain (TKD) of the epidermal growth factor receptor (EGFR) often exhibit dramatic sensitivity to the EGFR tyrosine kinase inhibitors gefitinib and erlotinib. Ionizing radiation (IR) is frequently used in the treatment of NSCLC, but little is known how lung tumor-acquired EGFR mutations affect responses to IR. Because this is of great...
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