Article
Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations.
International journal of oncology - 1 Nov 2012
Galimberti Fabrizio, Busch Alexander M, Chinyengetere Fadzai, Ma Tian, Sekula David, Memoli Vincent A, Dragnev Konstantin H, Liu Fang, Johnson Kevin C, Guo Yongli, Freemantle Sarah J, Andrew Angeline S, Greninger Patricia, Robbins David J, Settleman Jeff, Benes Cyril, Dmitrovsky Ethan
Abstract excerpt
Hedgehog (HH) pathway Smoothened (Smo) inhibitors are active against Gorlin syndrome-associated basal cell carcinoma (BCC) and medulloblastoma where Patched (Ptch) mutations occur. We interrogated 705 epithelial cancer cell lines for growth response to the Smo inhibitor cyclopamine and for expressed HH pathway-regulated species in a linked genetic database. Ptch and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.