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Article

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.

Nature - 31 Aug 2000

Taipale J, Chen J K, Cooper M K, Wang B, Mann R K, Milenkovic L, Scott M P, Beachy P A

Abstract excerpt

Basal cell carcinoma, medulloblastoma, rhabdomyosarcoma and other human tumours are associated with mutations that activate the proto-oncogene Smoothened (SMO) or that inactivate the tumour suppressor Patched (PTCH). Smoothened and Patched mediate the cellular response to the Hedgehog (Hh) secreted protein signal, and oncogenic mutations affecting these proteins cause excess activity of the Hh response pathway....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10984056
DOI: 10.1038/35023008

Genes

SMO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.PMID 10984056Read ↗

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Cyclopamine: from cyclops lambs to cancer treatment.Semantic proximity Read ↗

Beyond cyclopamine: Targeting Hedgehog signaling for cancer interventionSemantic proximity Read ↗

The role of hedgehog signalling in tumorigenesis.Semantic proximity Read ↗

Basal cell nevus syndrome.Semantic proximity Read ↗

Teratogen-Mediated Inhibition of Target Tissue Response to <i>Shh</i> SignalingSemantic proximity Read ↗

A positive role for patched-smoothened signaling in promoting cell proliferation during normal head development in Drosophila.Semantic proximity Read ↗

Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling.Semantic proximity Read ↗

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