Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.

doi:10.1126/scitranslmed.3001599

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Article

Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.

Science translational medicine - 29 Sept 2010

Buonamici Silvia, Williams Juliet, Morrissey Michael, Wang Anlai, Guo Ribo, Vattay Anthony, Hsiao Kathy, Yuan Jing, Green John, Ospina Beatriz, Yu Qunyan, Ostrom Lance, Fordjour Paul, Anderson Dustin L, Monahan John E, Kelleher Joseph F, Peukert Stefan, Pan Shifeng, Wu Xu, Maira Sauveur-Michel, García-Echeverría Carlos, Briggs Kimberly J, Watkins D Neil, Yao Yung-mae, Lengauer Christoph, Warmuth Markus, Sellers William R, Dorsch Marion

Abstract excerpt

The malignant brain cancer medulloblastoma is characterized by mutations in Hedgehog (Hh) signaling pathway genes, which lead to constitutive activation of the G protein (heterotrimeric guanosine triphosphate-binding protein)-coupled receptor Smoothened (Smo). The Smo antagonist NVP-LDE225 inhibits Hh signaling and induces tumor regression in animal models of medulloblastoma. However, evidence of resistance was...

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PMID: 20881279
DOI: 10.1126/scitranslmed.3001599
PMCID: PMC3422576

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