Article
Prognostic significance of alterations in KRAS isoforms KRAS-4A/4B and KRAS mutations in colorectal carcinoma.
The Journal of pathology - 1 Dec 2009
Abubaker Jehad, Bavi Prashant, Al-Haqawi Wael, Sultana Mehar, Al-Harbi Sayer, Al-Sanea Nasser, Abduljabbar Alaa, Ashari Luai H, Alhomoud Samar, Al-Dayel Fouad, Uddin Shahab, Al-Kuraya Khawla S
Abstract excerpt
Somatic KRAS mutation is an early well-known event in colorectal carcinogenesis but a complete understanding of RAS function and dysfunction in colorectal cancer is still to come. Our aim was to study the incidence of KRAS mutation; KRAS splice variants: KRAS4A and KRAS4B; and their relationships with various clinico-pathological characteristics in colorectal cancer (CRC).In this study, 285 CRC cases were...
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